Judging from the before and after pictures, Meg Ryan may of had Botox injections and a possible facelift. But, the result looks natural and she definitely hasn't lost her charm. Also, she was smart not to over do it and get bad plastic surgery. Here's Meg Ryan before and after plastic surgery through the years. She had Botox injections around her mouth, eyes, and forehead. Also, you can't rule out the possibility of facial fillers in her cheeks.